3 Probiotical Strains Reduce Itching and Eczema Lesions

The role of the skin–gut axis in atopic dermatitis (AD/eczema) remains a subject of debate, limiting the use of non-pharmacological interventions such as probiotics and prebiotics. To improve the understanding of their potential as a monotherapy for stable mild cases of eczema, we conducted a real-life, multicenter, retrospective observational study in Italy. We administered three selected Probiotical bacteria: Bifidobacterium animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05 along with FOS (prebiotic) and riboflavin orally to patients with mild atopic dermatitis without a placebo control group, following up for 12 weeks. Clinical assessments using the Scoring Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and Three-Item Severity (TIS) score were conducted on 144 enrolled patients (average age: 25.1 ± 17.6 years). Notably, both itching (pruritus) and AD-related lesions (erythema, edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001) after 12 weeks of exclusive probiotic and prebiotic use. Itching is a major and often debilitating symptom of atopic dermatitis. These preliminary results suggest a potential link between the skin–gut microbiome and support the rationale for using specific probiotics and prebiotics in mild AD, even for maintenance, to reduce flares. This may be mediated in part by improvement in barrier function in the gut.

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