BIFISLIM Adults
Cardiometabolic Health
Produces conjugated linoleic acid (CLA)
Reduces oxidative stress
Supports a healthy intestinal barrier
Reduces fat absorption
Reduces hunger
Bifidobacterium longum BL04 (DSM 23233)
Pricky pear (Opuntia ficus indica L.), pads, d.e.
Griffonia (Griffonia simplicifolia DC.) Baill., seeds
Bifidobacterium longum BL04 is a notable converter of linoleic acid (LA) into conjugated linoleic acids (CLA) [1]. CLA is recognized for its role in regulating cholesterol homeostasis, mitigating atherosclerotic damage, and maintaining cardiovascular function. It has also been shown to reduce body fat and positively impact blood lipids in animal and in vitro models. Furthermore, B. longum 04 has demonstrated efficacy in reducing ROS (Reactive Oxygen Species) production in cellular models aimed at restoration and prevention. It also exhibits antipathogenic activities and contributes to the protection and restoration of membrane integrity [1].
Prickly pear pads, known for their high fiber content, have been shown to promote weight loss in a 3-month clinical investigation [2]. In vitro studies have demonstrated that cactus fiber can bind to dietary fat, leading to reduced absorption. This, in turn, results in decreased energy absorption, contributing to the reduction of body weight.
Griffonia simplicifolia beans are rich in 5-HTP (5-Hydroxytryptophan), a crucial neurotransmitter that influences brain and central nervous system activity by increasing endogenous serotonin synthesis. It is also a direct precursor to melatonin. Due to these biochemical roles, 5-HTP from Griffonia phytocomplex is effectively used in conditions where serotonin plays a central role, such as depression, obesity, and insomnia. Particularly in overweight subjects, 5-HTP has been shown to decrease the sense of hunger through a central mechanism of action [3].
1. Internal Probiotical data
2. Uebelhack R, et al. Effects of cactus fiber on the excretion of dietary fat in healthy subjects: a double blind, randomized, placebo-controlled, crossover clinical investigation. Curr Ther Res Clin Exp. 2014 Jun 21;76:39-44. doi: 10.1016/j.curtheres.2014.02.001
3. Heisler LK, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006 Jul 20;51(2):239-49. doi: 10.1016/j.neuron.2006.06.004
4. Visciglia A., et al. Probiotics and Gut-Brain Axis: Insights on local and systemic mechanisms of action. Poster from the 12th Probiotics, Prebiotics & New Foods, Nutraceutical and Botanicals for Nutrition & Human and Microbiota Health, held in Rome on 12-14 September 2021.