BIFIFERT Man
Urology
- Antioxidant activity
- Produces folate
Lactobacillus plantarum LP01 (LMG P-21021)
Bifidobacterium animalis subsp. lactis BA05 (DSM 18352)
Zinc
N-acetyl-L-cysteine (NAC)
Selenium
Label claim (Europe)
Zinc contributes to normal fertility and reproduction, and to normal DNA synthesis and to the mainteinance of normal testosterone levels.
Zinc and Selenium contribute to the protection of cells from oxidative stress.
Selenium contributes to normal spermatogenesis.
Biotin
EFSA Claim: contributes to the mantainance of normal mucosas
Vitamin C
EFSA Claim: Vitamin C contributes to the protection of cells from oxidative stress.
The probiotic strain Bifidobacterium lactis BA05 is selected for its unique ability to produce 5-methyltetrahydrofolate (5-MTHF), the active form of folic acid, a capability that has been demonstrated in in vitro, preclinical, and clinical trials [1-3]. Supplementation with 5-MTHF-producing bacteria like BA05 offers an endogenous, auto-regulated source of folic acid, ensuring a steady bioavailability of vitamin B9, unlike traditional exogenous supplementation [3].
Zinc plays a crucial role in sperm formation, and folate, the natural form of folic acid, relies on zinc for DNA formation in sperm [4]. Oxidative stress is believed to affect male fertility parameters in approximately 40-50% of cases [5]. Antioxidants are vital in improving the quality of spermatozoa, with numerous studies highlighting their positive effects on sperm motility and morphology [6].
BIFIFERT® Man combines various sources of antioxidants, including probiotics:
- Lactobacillus plantarum LP01 has shown strong antioxidant activity in an in vitro study, significantly reducing ROS (Reactive Oxygen Species) levels [7].
- Zinc: An essential mineral with various biological functions. Research has emphasized the importance of zinc in male fertility, noting that seminal zinc concentration correlates with sperm count. Zinc deficiency in the diet is linked to poor sperm quality and male infertility [8-11].
- N-acetyl-L-cysteine (NAC): This antioxidant scavenges free radicals and is used as a supplement to counteract glutathione (GSH) depletion during oxidative stress [12,13].
- Selenium: A vital trace mineral and a key component of selenoproteins. Selenium is crucial for normal spermatogenesis, sperm maturation, sperm motility, and overall reproductive functions in males. Increased dietary intake of Selenium is associated with enhanced antioxidant activity of glutathione peroxidase (GPX), which is beneficial for male fertility [14].
