BIFIFERT Woman

The probiotic strain Bifidobacterium lactis BA05 has been specifically chosen for its unique ability to produce 5-methyltetrahydrofolate (5-MTHF), the active form of folic acid. This capability has been substantiated through in vitro, preclinical, and clinical studies [1-3]. The supplementation with 5-MTHF-producing bacteria offers an endogenous and auto-regulated source of folic acid, ensuring consistent bioavailability of vitamin B9, which contrasts with traditional exogenous supplementation methods.

Vaginal infections can adversely affect fertility through various mechanisms: 1) by escalating inflammation and oxidative stress, creating a detrimental environment for the oocyte; 2) by causing damage to sperm and vaginal cells; 3) by disrupting the production of cervical mucus during ovulation; and 4) by damaging fallopian tubes, potentially leading to blockages from scar tissue formation and hindering the meeting of egg and sperm cells.

Oxidative stress is known to impair fertility by interfering with crucial reproductive processes such as folliculogenesis, fertilization, implantation, and placentation [4].

Bifidobacterium lactis BS01 has been selected to specifically target oxidative stress in women. It has shown significant gender-specific antioxidant activity in an in vitro study, markedly reducing ROS (Reactive Oxygen Species) levels [5].

Lactobacillus salivarius CRL 1328, a promising vaginal probiont isolated from a healthy vaginal environment, has demonstrated successful binding to epithelial cells — a key step in probiotic colonization. It significantly reduces the adherence of the urogenital pathogen Staphylococcus aureus. Additionally, this strain co-aggregates with Candida albicans, enhancing the yeast's sedimentation rate. It also produces salivaricin CRL 1328, which inhibits the growth of various pathogens, including certain strains of Enterococcus spp., Enterococcus faecalis, and Neisseria gonorrhoeae [6-10].

Bacterial vaginosis is associated with an increased risk of infertility, particularly tubal infertility. Idiopathic infertility has been connected to a distinct vaginal bacterial signature that includes bacteria related to bacterial vaginosis [11].

Inositol plays a critical role in follicular gonadotropin pathways, which orchestrate ovulation. Recent studies have underscored the beneficial action of inositol, confirming its essential role in FSH signaling, oocyte maturation, and embryo development. Elevated inositol concentrations in human follicular fluid are associated with follicular maturity and have been proposed as a potential marker of high-quality oocytes [12].

Folate is crucial for the proper development of maternal tissues [1].