PROBIAL IMMUNE 1

PROBIAL® IMMUNE 1 is a tailored formulation designed to bolster the immune system, aiding the body in responding to pathogenic attacks and swiftly resolving associated symptoms.

Bifidobacterium lactis BS05: Reactive species play a physiological role in both innate and adaptive immune responses, targeting pathogen infiltration. During pathogen exposure, phagocytes generate reactive oxygen species (ROS) through oxidative bursts to combat pathogens [1,2]. BS05 has exhibited strong antioxidant activity, protecting cells from oxidative damage by stimulating the production of SOD (Superoxide dismutase) and GSH (reduced glutathione) [3].

Bifidobacterium lactis BS01: In in vitro studies, BS01 has been shown to stimulate immunosurveillance, activating the immune system to prepare for fighting infectious pathogens. BS01 can stimulate the differentiation of monocytes into Dendritic Cells (DCs) and the proliferation of Natural Killer cells (NKs) [4,5]. It also promotes the secretion of two different interferons [5]:

• IFN-α: Direct antiviral action, limiting viral replication.
• IFN-γ: Involved in the late phase of infection, signaling virus-infected cells and stimulating an immune response against them.

Bifidobacterium longum BL03: Through the release of metabolic products, BL03 can inhibit the binding of the RBD of the spike proteins of SARS-CoV-2 to the human ACE2 receptor, a key pathway for viral entry into host cells [6].

BS01 and BL03: Both strains are capable of protecting and restoring membrane integrity after damage induced by proinflammatory stimuli, counteracting leaky gut. This is particularly relevant as intestinal dysbiosis and resulting leaky gut can exacerbate infection severity by allowing viruses to access internal organs.

Vitamin D: Known primarily for its role in calcium homeostasis, vitamin D3 also exhibits significant immunostimulating and immunomodulating activities. Studies have indicated its ability to modulate the immune system towards a Th1 response, aiding the body's defense against viral and bacterial attacks [7].