PROBIAL STONE

Kidney stones, also known as nephrolithiasis, urolithiasis, or renal/kidney calculi, rank as the second most common chronic kidney disease following hypertension [1]. A primary component of most kidney stones is calcium oxalate, which is primarily introduced into the body through dietary sources. One major risk factor for kidney stones is increased enteric oxalate absorption, leading to hyperoxaluria, and reducing the intestinal absorption of oxalates can be crucial in preventing stone formation [2].

PROBIAL® Stone is a probiotic supplement specifically developed as a novel approach to preventing kidney stones. It includes selected lactobacilli strains known for their specific benefits:

• Lactobacillus acidophilus LA02 and Lacticaseibacillus paracasei LPC09: These strains have demonstrated the ability to degrade oxalates in vitro [4]. By reducing intestinal oxalate absorption, they help protect against hyperoxaluria. Additionally, these lactobacilli possess antagonistic activities against certain hemolytic pathogens, particularly Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa [3]. These pathogens are commonly found in urinary tract infections (UTIs) in patients with urolithiasis.

By counteracting pathogenic overgrowth and reducing oxalate absorption, PROBIAL® Stone can play a role in preventing both the formation of kidney stones and the occurrence of UTIs, which are frequent in individuals with urolithiasis. This dual-action approach makes PROBIAL® Stone a potentially valuable supplement for individuals at risk of developing kidney stones and associated complications.