Gynecology
Supports treatment and prevention of cystitis
Counteracts pathogenic E. coli
Helps restore intestinal membrane integrity
Source of cranberry and D-mannose







Streptococcus thermophilus ST10 (DSM 25246)
Lactiplantibacillus plantarum LP01 (LMG P-21021)
Lacticaseibacillus paracaseiLPC09 (DSM 24243)
Cranberry (Vaccinium macrocarpon Aiton), fruit, d.j.
Proanthocyanidins (PACs)
D-Mannose
Food supplement with probiotic strains.
Biotin
EFSA Claim: contributes to the mantainance of normal mucosa
Urinary tract infections (UTIs) remain among the most common bacterial infections, affecting approximately 150 million people worldwide each year [1,2]. They are caused by a variety of pathogens, primarily due to the ascent of intestinal bacteria, with uropathogenic E. coli (UPEC) being the predominant cause. Most UTIs are acute uncomplicated cystitis caused by E. coli (86%), though other microbes like Staphylococcus saprophyticus (4%), Klebsiella spp. (3%), Enterobacter spp. (1.4%), and Enterococcus spp. (0.5%) can also be involved [2,3]. UPEC accounts for about 80% of UTIs, typically triggering an inflammatory response and bacteriuria. The primary treatment for cystitis usually involves antibiotics; however, due to bacterial biofilm formation, antibiotic treatment often fails to completely eradicate the infection, leading to persistent bacteriuria and recurrences [4-8].
BIFICIST® is a food supplement combining specific probiotic strains, cranberry extract, and D-mannose, offering a dual and synergistic mechanism of action at both urinary and intestinal levels, enhancing the management of recurrent UTIs. The probiotic component of BIFICIST® includes Streptococcus thermophilus ST10, which synthesizes exopolysaccharides (EPS) in the gut lumen, Lactiplantibacillus plantarum LP01 and Lacticaseibacillus paracasei LPC09, known for their specific activities against E. coli [9] and other beneficial properties like anti-inflammatory activities [10] and protection/restoration of intestinal membrane integrity. Moreover, LPC09 is notably efficient in vitro at metabolizing oxalates, potentially offering protection from gut inflammation associated with prolonged supplementation with cranberry dry extract.
D-Mannose, a simple sugar closely related to glucose, is the primary bladder cell receptor site for uropathogenic E. coli [13]. It exerts its effects locally in the urinary bladder by binding to UPEC, which remains free in urine and is thus more easily eliminated during urination [14]. Scientific studies suggest that D-Mannose can be an effective aid in managing acute cystitis and as a prophylactic agent.
Cranberries, known for their antimicrobial activity against E. coli, create a natural physical-mechanical barrier against the adhesion of E. coli to the epithelial cells of the bladder and urinary tract, thus preventing UTI recurrence. BIFICIST® has been clinically studied in adult women with uncomplicated cystitis [19], showing significant improvement in symptoms like dysuria, frequent voiding, and urgency over 60 days of treatment (30 days of acute treatment with 2 sachets/day + 30 days of long-term treatment with 1 sachet/day). The study also recorded a low number of recurrences during the 1-month follow-up after treatment, suggesting a long-term barrier effect exerted by the product.
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11. Internal Probiotical’s data
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