PROBIAL Age
Healthy Aging
- Supports healthy immunity
- Protects from oxidative stress
- Highly bioavailable source of zinc
- Anti-inflammatory activity
Bifidobacterium lactis BS05 (DSM 23032)
Lactiplantibacillus plantarum LP01 (DSM 16605)
Limosilactobacillus reuteriLb26 (DSM 16341) tyndallized
20 mg Selenium
27.5 mcg 50% Zinc
(Europe): Zinc contributes to normal DNA synthesis, and to normal cognitive function. Together with Selenium, Zinc contributes to the protection of cells from oxidative stress.
Vitamin C
EFSA claim: contributes to maintain the normal function of the immune system
Vitamin D3
EFSA claim: contributes to maintain normal bones and teeth
Oxidative stress is a major factor in the premature aging of the body, adversely affecting the functionality of all tissues. Recent studies have highlighted the role of dietary antioxidants in controlling the body's oxidative state. PROBIAL® Age is specially formulated to combat local and systemic oxidative stress, featuring probiotics and minerals known for their antioxidant and anti-inflammatory activities:
Bifidobacterium lactis BS05: Exhibits strong antioxidant activity by stimulating the production of SOD (Superoxide dismutase) and GSH (reduced glutathione) within the cell [1].
Lactiplantibacillus plantarum LP01: Demonstrated significant anti-inflammatory and antioxidant activities in two in vitro studies, including a robust decrease in ROS (Reactive Oxygen Species) levels [2,3].
Limosilactobacillus reuteri Lb26 tyndallized: In in vitro studies, Selenium internalized by Lb26 showed higher bioavailability compared to other forms of selenium, with absorption by Caco-2 cells being [4-7]:
Over 6 times higher than sodium selenite.
9 times higher than seleno-L-methionine.
65 times higher than seleno-L-cysteine.
Additionally, it was the only form that reached higher concentrations in the Transwell basolateral compartment compared to the apical department.
Selenium (Se): An essential trace mineral and a vital component of selenoproteins. It plays a key role in reducing reactive oxygen species-mediated inflammation, minimizing DNA damage, prolonging telomere length, and thus combating aging and preventing aging-related diseases [8,9].
Zinc (Zn): An essential element with diverse biological functions. Zinc deficiency, common in the elderly, leads to changes similar to those seen in oxidative inflammatory aging and immunosenescence [10]. Some studies have shown benefits of zinc supplementation in enhancing immune function.
PROBIAL® Age has undergone clinical testing in geriatric patients receiving home enteral nutrition (HEN). A 2-month supplementation regimen in this critical target population was found to be safe and easy to administer, showing its potential benefits in supporting healthy aging [11].
1. Amaretti A. et al. Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities. Appl Microbiol Biotechnol. 2013; 97(2):809-17. Doi: 10.1007/s00253-012-4241-7
2. Amoruso A. et al. A Systematic Evaluation of the Immunomodulatory and Functional Properties of Probiotic Bifidobacterium Breve BR03 (DSM 16604) Lactobacillus plantarum LP01 (LMG P-21021). J Prob Health. 2019; 7:214. Doi: 10.35248/2329-8901.19.7.214
3. Magistrelli L. et al. Probiotics May Have Beneficial Effects in Parkinson's Disease: In vitro Evidence. Front Immunol. 2019 May 7;10:969. doi: 10.3389/fimmu.2019.00969
4. Mogna L. et al. Selenium and zinc internalized by Lactobacillus buchneri Lb26 (DSM 16341) and Bifidobacterium lactis Bb1 (DSM 17850): improved bioavailability using a new biological approach. J Clin Gastroenterol. 2012; 46 Suppl:S41-5. DOI: 10.1097/MCG.0b013e318268861d
5. Mangiapane E. et al. An integrated proteomic and physiological approach to understand the adhesion mechanism of the probiotic Lactobacillus reuteri Lb26 DSM16341. J Integ Omics. 2013 Dec;3(2):145-146. DOI: 10.5584/jiomics.v3i2.143
6. Galano E. et al. Privileged Incorporation of Selenium as Selenocysteine in Lactobacillus reuteri Proteins Demonstrated by Selenium-specific Imaging and Proteomics. Mol Cell Proteomics. 2013 Aug;12(8):2196-204. DOI: 10.1074/mcp.M113.027607
7. Mangiapane E. et al. Selenium effects on the metabolism of a Semetabolizing Lactobacillus reuteri: analysis of envelope-enriched and extracellular proteomes. Mol Biosyst. 2014 Jun;10(6):1272-80. DOI: 10.1039/c3mb70557a
8. Mangiapane E. et al. Selenium and Selenoproteins: An Overview on Different Biological Systems. Curr Protein Pept Sci. 2014;15(6):598-607. DOI: 10.2174/1389203715666140608151134
9. Cai Z, et al. Selenium, aging and aging-related diseases. Aging Clin Exp Res. 2019 Aug;31(8):1035-1047. doi: 10.1007/s40520-018-1086-7
10. Cabrera ÁJ. Zinc, aging, and immunosenescence: an overview. Pathobiol Aging Age Relat Dis. 2015 Feb 5;5:25592. doi: 10.3402/pba.v5.25592
11. Orlandoni P, et al. Safety and Efficacy of Probiotic Supplementation in Reducing the Incidence of Infections and Modulating Inflammation in the Elderly with Feeding Tubes: A Pilot, Double-Blind, Placebo-Controlled Study, “IntegPRO”. Nutrients. 2021 Jan 27;13(2):391. doi: 10.3390/nu13020391
