Dermatology

Developed Formulas
Benefits
  • Promotes skin normalization in atopic dermatitis
  • Antipathogenic activity against Staphylococcus aureus
  • Stimulates anti-inflammatory IL-10 cytokine
  • Promotes skin renewal
Dermatology
In vitro test
Dermatology
Allergen Free
Dermatology
Real time stability
Dermatology
Strain in oil
Dermatology
Capsules
Components

Lactiplantibacillus plantarum LP14 (DSM 33401)
Bifidobacterium lactis BS01 (LMG P-21384)
Lacticaseibacillus rhamnosus LR05 (DSM 19739)
Riboflavin (vitamin B2)
FOS (Fructooligosaccharides)

Label Claim


 

Effective nutraceutical combination
Scientific Rationale
In vitro studies

This probiotic formulation is specifically designed for atopic dermatitis and aims to restore physiological skin conditions in those with an atopic tendency:

  • Lactiplantibacillus plantarum LP14: This strain is notable for its ability to produce riboflavin [1]. It is also effective in inhibiting the growth of Staphylococcus aureus, a primary pathogenic strain in atopic dermatitis [2]. Additionally, LP14 helps in restoring membrane integrity following damage induced by pro-inflammatory stimuli [3].

  • Bifidobacterium lactis BS01 and Lacticaseibacillus rhamnosus LR05: These strains have been shown to induce elevated IL-10 secretion, alongside a shift from a Th2- to a more Th1- and Th17-like phenotype [3]. In a clinical trial, 2 and 4 months of administration of BS01 and LR05 demonstrated positive effects on skin normalization in atopic dermatitis [4]. This included a reduction in the SCORAD (Severity Scoring of Atopic Dermatitis) index and a concurrent decrease in the use of corticosteroids, antihistamine drugs, and calcineurin inhibitors.

  • Riboflavin: Also known as Vitamin B2, riboflavin plays a crucial role in skin renewal processes. It's essential for maintaining healthy skin, particularly in conditions where skin repair and regeneration are necessary.

Bibliography

1. Internal Probiotical data

2. Deidda F, et al. How Probiotics may Kill Harmful Bacteria: The in vitro Activity against Some Haemolytic Strains. J Prob Health, 2020. Vol. 8 Iss.2 No: 216.  DOI: 10.35248/2329-8901.20.8.216

3. Heldner A, et al. Ex Vivo Immunomodulatory Effects of Lactobacillus-, Lacticaseibacillus-, and Bifidobacterium-Containing Synbiotics on Human Peripheral Blood Mononuclear Cells and Monocyte-Derived Dendritic Cells in the Context of Grass Pollen Allergy. Probiotics Antimicrob Proteins. 2023 Aug;15(4):868-879. DOI: 10.1007/s12602-022-09920-w

4. Manzotti G. et al. Probiotics as a Novel Adjuvant Approach to Atopic Dermatitis. J Contemp Immunol. 2014; 1(2): 57-66. DOI:10.7726/JCI.2014.1007

Associations