VITALONGUM

The gut microbiota of centenarians, when compared to that of younger adults, shows a distinctive presence of Bifidobacterium longum, which is believed to be a characteristic feature of longevity [1,2]. B. longum is recognized for its probiotic properties and has been found effective in managing inflammatory status, cholesterol levels, lactose intolerance, and in preventing infectious diarrhea and other infections [3,4].

Vitalongum® contains three strains of Bifidobacterium longum that were isolated from the gut microbiota of centenarian subjects. These strains share biological similarities and are known for their ability to stimulate the synthesis of specific cytokines, both individually and in combination [5]. Their cytokine stimulation profiles differ from strains not derived from centenarians, suggesting a unique beneficial impact associated with longevity.

Furthermore, oxidative stress is acknowledged as a primary factor contributing to premature aging, negatively affecting tissue functionality throughout the body. Recent studies have emphasized the role of antioxidants in the diet in controlling the body's oxidative state, underlining their importance in promoting health and longevity [6].

• Selenium: This element plays a vital role in the normal functioning of the immune system and thyroid function. Additionally, selenium is crucial for the protection of cells from oxidative stress, thereby contributing to overall health and potentially to longevity.

• Zinc: Zinc is essential for normal cognitive function, DNA synthesis, and acid-base metabolism. Like selenium, zinc also contributes to the protection of cells from oxidative stress, further supporting its role in maintaining health and combating the aging process.