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Gastroenterology

IBS / Constipation

Functionality

Reduces constipation

Improves intestinal transit

Anti-inflammatory activity

Eases gastrointestinal discomfort

Inhibits pathogenic E. coli and other pathogens

Reduces IBS pain

Dosage / Clinical Study

1) LP01 5 billion CFU + BR03 5 billion CFU

2, 3) LP01 2.5 billion CFU + BR03 2.5 billion CFU

Available Formats

Single strain

Blend

Finished dosage form

Scientific Support
Clinical studies

1)  Saggioro A. Probiotics in the treatment of irritable bowel syndrome. J Clin Gastroenterol. 2004 Jul;38(6 Suppl):S104-6. doi: 10.1097/01.mcg.0000129271.98814.e2. (BR03 reported as BR0)

2) Del Piano M. et al. The use of probiotics in healthy volunteers with evacuation disorders and hard stools. A double blind, randomized, placebo controlled study. J Clin Gastroenterol, 2010; 44(8):S30-34. doi:10.1097/MCG.0b013e3181ee31c3

3)  Dimidi E. et al. The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 2014;100:1075–84. doi: 10.3945/ajcn.114.089151

In vitro studies

a) Mogna L. et al. Assessment of the In Vitro Inhibitory Activity of Specific Probiotic Bacteria Against Different Escherichia coli strains. J. Clin. Gastroenterol. 2012;46 Suppl.S29-32.  Doi: 10.1097/MCG.0b013e31826852b7

b) Nicola S. et al. Interaction between probiotics and human immune cells: the prospective anti-inflammatory activity of Bifidobacterium breve BR03. AgroFOOD, 2010; 21(2):S44-47.

c) Amoruso A. et al. A Systematic Evaluation of the Immunomodulatory and Functional Properties of Probiotic Bifidobacterium Breve BR03 (DSM 16604) Lactobacillus plantarum LP01 (LMG P-21021). J Prob Health. 2019;  7:214. Doi: 10.35248/2329-8901.19.7.214

d) Deidda F, et al. How Probiotics may Kill Harmful Bacteria: The in vitro Activity against Some Haemolytic Strains. J Prob Health, 2020. Vol. 8 Iss.2 No: 216.  DOI: 10.35248/2329-8901.20.8.216                                              

Internal in vitro data on gut permeability available upon request

Associations