LS01™ + BR03™ (BIFIDERM)

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Dermatology

Inflammatory skin conditions

Functionality

Improves atopic dermatitis symptoms

Reduces bacterial translocation across gut barrier

Improves inflammatory scalp rosacea

Reduces refractory urticaria symptoms

Dosage / Clinical Study

1, 3, 4) LSO1 2 billion CFU + BR03 2 billion CFU
2) LSO1 1 billion CFU + BR03 1 billion CFU

Available Formats

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Finished dosage form

Scientific Support
Clinical studies

1) Iemoli E. et al. Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. J Clin Gastroenterol. 2012 Oct;46 Suppl:S33-40. doi: 10.1097/MCG.0b013e31826a8468

2) 2) Licari A. et al. Efficacia clinica di Lactobacillus salivarius LS01 e Bifidobacterium breve BR03 in pazienti pediatrici affetti da dermatite atopica. Il medico pediatra 2016;38-42.

3) Fortuna MC. et al. A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options. Dermatol Ther. 2016 Jul;29(4):249-51. doi: 10.1111/dth.12355

4) Nettis E. et al. Probiotics and refractory chronic spontaneous urticaria. Eur Ann Allergy Clin Immunol. 2016 Sep;48(5):182-7. PMID: 27608474.

In vitro studies

a) Deidda F, et al. New Approach in Acne Therapy: A Specific Bacteriocin Activity and a Targeted Anti IL-8 Property in Just 1 Probiotic Strain, the L. salivarius LS03. J Clin Gastroenterol. 2018 Nov/Dec;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S78-S81. doi: 10.1097/MCG.0000000000001053. 

b) Drago L. et al.  Immunomodulatory Effects of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03, Alone and in Combination, on Peripheral Blood Mononuclear Cells of Allergic Asthmatics. Allergy Asthma Immunol Res. 2015 Jul;7(4):409-13. doi: 10.4168/aair.2015.7.4.409.

c) Deidda F, et al. How Probiotics may Kill Harmful Bacteria: The in vitro Activity against Some Haemolytic Strains. J Prob Health, 2020. Vol. 8 Iss.2 No: 216.  DOI: 10.35248/2329-8901.20.8.216

d) Nicola S. et al. Interaction between probiotics and human immune cells: the prospective anti-inflammatory activity of Bifidobacterium breve BR03. AgroFOOD, 2010; 21(2):S44-47

e) Mogna L. et al. Assessment of the In Vitro Inhibitory Activity of Specific Probiotic Bacteria Against Different Escherichia coli strains. J. Clin. Gastroenterol. 2012;46 Suppl.S29-32.  Doi: 10.1097/MCG.0b013e31826852b7

Associations