PROBIAL IMMUNE 2

PROBIAL® IMMUNE 2 is a formulation developed to enhance the immune system, counteract the colonization of pathogenic bacteria, and support energy-yielding metabolism.

Bifidobacterium lactis BS01: This strain has been shown in in vitro studies to stimulate immunosurveillance, meaning it can activate the immune system in a way that prepares it to combat infectious pathogens. Specifically, BS01 can stimulate the differentiation of monocytes into Dendritic Cells (DCs) and the proliferation of Natural Killer cells (NKs), as well as promote the secretion of two different interferons [1,2]:

• IFN-α: Provides direct antiviral action, limiting viral replication.

• IFN-γ: Plays a role in the late phase of infection by signaling virus-infected cells and stimulating an immune response against them.

Lactiplantibacillus plantarum LP14: Exhibits strong direct inhibition against many nosocomial pathogenic microorganisms, such as Enterococcus faecalis, Klebsiella pneumoniae, E. coli, and Staphylococcus aureus, thanks to genes coding for bacteriocins [3]. Additionally, LP14 can inhibit the binding of the RBD of the spike proteins of SARS-CoV-2 to the human ACE2 receptor, which is crucial for the virus's entry into host cells [4].

BS01 and LP14: Both strains are capable of protecting and restoring membrane integrity after damage induced by a proinflammatory stimulus, which is beneficial in combating leaky gut [2]. This is particularly important in the context of COVID-19, where intestinal dysbiosis and the resultant leaky gut can worsen the severity of infections by allowing the virus to penetrate the weakened gut lining and access internal organs.

Vitamin C: Widely recognized for its immune-stimulating activity, various studies have demonstrated its effectiveness in reducing recovery time from winter diseases, while also alleviating related sensations of fatigue and tiredness.