BL04 + LF16 + LP01™ + LR06 (BIFIZEN)
Neurology
Mood / Sleep quality
Supports healthy sleep
Supports healthy mood
Supports alertness and calmness
1) 4 billion CFU/AFU total
4) 1 billion AFU per strain [Microbac encapsulated]
Blend
Finished dosage form
1) Marotta A, et al. Effects of Probiotics on Cognitive Reactivity, Mood, and Sleep Quality. Front Psychiatry. 2019 Mar 27;10:164. doi: 10.3389/fpsyt.2019.00164.
2) Irwin C, et al. Effects of probiotics and paraprobiotics on subjective and objective sleep metrics: a systematic review and meta-analysis. Eur J Clin Nutr. 2020 Nov;74(11):1536-1549. https://doi.org/10.1038/s41430-020-0656-x
3) Calgaro M, et al. Metabarcoding analysis of gut microbiota of healthy individuals reveals impact of probiotic and maltodextrin consumption. Benef Microbes. 2021 Apr 12;12(2):121-136. doi: 10.3920/BM2020.0137
4) Walden KE, et al. A randomized controlled trial to examine the impact of a multi-strain probiotic on self-reported indicators of depression, anxiety, mood, and associated biomarkers. Front Nutr. 2023 Aug 31;10:1219313. doi: 10.3389/fnut.2023.1219313
Data on the preclinical rationale for strain selection is available upon request
a) Mogna L. et al. Assessment of the In Vitro Inhibitory Activity of Specific Probiotic Bacteria Against Different Escherichia coli strains. J. Clin. Gastroenterol. 2012;46 Suppl.S29-32. Doi: 10.1097/MCG.0b013e31826852b7 [LP01, LR06 strain data]
b) Deidda F, et al. How Probiotics may Kill Harmful Bacteria: The in vitro Activity against Some Haemolytic Strains. J Prob Health, 2020. Vol. 8 Iss.2 No: 216. DOI: 10.35248/2329-8901.20.8.216 [LP01 strain data]
c) Amoruso A. et al. A Systematic Evaluation of the Immunomodulatory and Functional Properties of Probiotic Bifidobacterium Breve BR03 (DSM 16604) Lactobacillus plantarum LP01 (LMG P-21021). J Prob Health. 2019; 7:214. Doi: 10.35248/2329-8901.19.7.214 [BR03 strain data]
d) Visciglia A., et al. Probiotics and Gut-Brain Axis: Insights on local and systemic mechanisms of action. Poster from the 12th Probiotics, Prebiotics & New Foods, Nutraceutical and Botanicals for Nutrition & Human and Microbiota Health, held in Rome on 12-14 September 2021.
e) De Prisco A. et al. Strain-specific Production of GABA by Lactobacilli and Bifidobacteria Probiotics. Poster from the 15th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health – IPC2022, held in Bratislava on 27-30 June 2022
