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Lacticaseibacillus rhamnosus LR04 (DSM 16605) (formerly Lactobacillus rhamnosus)

Single strain
Single strain
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Allergy & Immunology

Respiratory health

Functionality

Supports a healthy response to environmental pathogens [in vitro]

Available Formats

Single strain

Blend

Finished dosage form

Scientific Support
In vitro studies

a) Visciglia A. et al. Probiotics: a potential therapeutic strategy in respiratory infections. Poster from the 12th Probiotics, Prebiotics & New Foods, Nutraceutical and Botanicals for Nutrition & Human and Microbiota Health, held in Rome on 12-14 September 2021

For information on blends containing LR04 see the following Blends pages:

  • BIFIMMUN®
  • BIFIVIR®
  • LACTARRHEA®
  • PROBIAL® Stomach
  • FLOR-EN® Baby
  • CELIAFLORA™ ADULTS
  • CELIAFLORA™ IBD ADULTS

Gastroenterology

GI Health

Functionality

May support healthy intestinal physiology [animal model/in vitro]

May support a healthy gut microbiota [in vitro]

May support gut barrier integrity [animal model/in vitro]

Available Formats

Single strain

Blend

Finished dosage form

Scientific Support
In vitro studies

a) Mogna L, et al. Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains. J Clin Gastroenterol. 2012; 46 Suppl:S29-32. Doi: 10.1097/MCG.0b013e31826852b7

b) Deidda F, et al. How Probiotics may Kill Harmful Bacteria: The in vitro Activity against Some Haemolytic Strains. J Prob Health, 2020. Vol. 8 Iss.2 No: 216.  DOI: 10.35248/2329-8901.20.8.216

c) Chamignon C et al. Evaluation of the Probiotic Properties and the Capacity to Form Biofilms of Various Lactobacillus Strains. Microorganisms. 2020 Jul 15;8(7):1053. DOI: 10.3390/microorganisms8071053

d) Chamignon C, et al. Beneficial Effects of Lactobacilli Species on Intestinal Homeostasis in Low-Grade Inflammation and Stress Rodent Models and Their Implication in the Modulation of the Adhesive Junctional Complex. Biomolecules. 2023 Aug 24;13(9):1295.  DOI: 10.3390/biom13091295

For information on blends containing LR04 see the following Blends pages:

  • BIFIMMUN®
  • BIFIVIR®
  • LACTARRHEA®
  • PROBIAL® Stomach
  • FLOR-EN® Baby
  • CELIAFLORA™ ADULTS
  • CELIAFLORA™ IBD ADULTS

Gastroenterology

GUT MICROBIOME DYSBIOSIS

Functionality

Inhibits pathogenic E. coli, E. faecalis, K. Pneumoniae, S. aureus and/or P. aeruginosa [in vitro]

Available Formats

Single strain

Blend

Finished dosage form

Scientific Support
In vitro studies

a) Mogna L, et al. Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains. J Clin Gastroenterol. 2012; 46 Suppl:S29-32. Doi: 10.1097/MCG.0b013e31826852b7

b) Deidda F, et al. How Probiotics may Kill Harmful Bacteria: The in vitro Activity against Some Haemolytic Strains. J Prob Health, 2020. Vol. 8 Iss.2 No: 216.  DOI: 10.35248/2329-8901.20.8.216

For information on blends containing LR04 see the following Blends pages:

  • BIFIMMUN®
  • BIFIVIR®
  • LACTARRHEA®
  • PROBIAL® Stomach
  • FLOR-EN® Baby
  • CELIAFLORA™ ADULTS
  • CELIAFLORA™ IBD ADULTS

Oral Care

ORAL HEALTH/MICROBIOME DYSBIOSIS

Functionality

Anti-pathogenic activity [in vitro] against the main pathogens involved in oral dysbiosis

Available Formats

Single strain

Scientific Support
In vitro studies

a) Zanetta P, et al. Selection of Probiotic Strains for Oral Health. Poster from the XIX CONGRESSO NAZIONALE CSID, held in Novara on 1-2 October, 2022

b) Zanetta P,et al. In Vitro Selection of Lactobacillus and Bifidobacterium Probiotic Strains for the Management of Oral Pathobiont Infections Associated to Systemic Diseases. Int J Mol Sci. 2022 Dec 18;23(24):16163. DOI: 10.3390/ijms232416163

c) Zanetta P, et al. Growth Conditions Influence Lactobacillus Cell-Free Supernatant Impact on Viability, Biofilm Formation, and Co-Aggregation of the Oral Periodontopathogens Fusobacterium nucleatum and Porphyromonas gingivalis. Biomedicines. 2023 Mar 11;11(3):859. DOI: 10.3390/biomedicines11030859

For information on blends containing LR04 see the following Blends pages:

  • BIFIMMUN®
  • BIFIVIR®
  • LACTARRHEA®
  • PROBIAL® Stomach
  • FLOR-EN® Baby
  • CELIAFLORA™ ADULTS
  • CELIAFLORA™ IBD ADULTS

Urology

urinary tract health

Functionality

Inhibits pathogenic E. coli [in vitro]

Available Formats

Single strain

Blend

Finished dosage form

Scientific Support
In vitro studies

a) Mogna L. et al. Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains. J Clin Gastroenterol. 2012; 46 Suppl:S29-32. Doi: 10.1097/MCG.0b013e31826852b7

b) Deidda F, et al. How Probiotics may Kill Harmful Bacteria: The in vitro Activity against Some Haemolytic Strains. J Prob Health, 2020. Vol. 8 Iss.2 No: 216.  DOI: 10.35248/2329-8901.20.8.216

For information on blends containing LR04 see the following Blends pages:

  • BIFIMMUN®
  • BIFIVIR®
  • LACTARRHEA®
  • PROBIAL® Stomach
  • FLOR-EN® Baby
  • CELIAFLORA™ ADULTS
  • CELIAFLORA™ IBD ADULTS

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